Long-term monitoring of the radio-galaxy M87 in gamma-rays: joint analysis of MAGIC, VERITAS and Fermi-LAT data

M87 was discovered in the very-high-energy band (VHE, E > 100 GeV) with HEGRA in 2003, long before its emission was detected in the high-energy band (HE, E > 100 MeV) with Fermi-LAT in 2009, opening the window to a new family of extragalactic sources with tilted jets. After a series of major VHE flares in 2005, 2008, and 2010, which were detected in multiple bands, the source has been found in a low activity state, interrupted only by comparatively smaller-scale flares. MAGIC and VERITAS, two stereoscopic Cherenkov telescope arrays located at Roque de los Muchachos Observatory (Canary Islands, Spain) and the Fred Lawrence Whipple Observatory (Arizona, US), have monitored M87 continuously and in coordination for more than 10 years. In this work, we present the data for 4 years of MAGIC and VERITAS observations corresponding to 2019, 2020, 2021 and 2022. The resulting light curves are shown in daily and monthly scales where no significant variability is observed. In addition, we show the first joint analysis using combined event data from the two VHE instruments and Fermi-LAT to compute the spectral energy distribution

Short communication: Effects of the addition of a marigold extract to diets fed to channel catfish (Ictalurus punctatus) on growth parameters

The expansion of aquaculture in the last 10 years has made it an important source of protein worldwide. However, increased production, and the culture intensification it carries, results in higher risk of infectious disease due to poor water quality and high stocking densities. ... Marigold (Tagetes erecta L.) is a plant native to Mexico whose flowers accumulate carotenoids. Natural carotenoids extracted from marigold have been used in aquaculture to help in the survival of fish juvenile stages by strengthening their immunological system, thus reducing mortality rates. The effect of carotenoids in fish health may exert a positive effect on fish growth indices; however, these effects on growth parameters have not been studied in channel catfish (Ictalurus punctatus), which is the most cultured fish species in north-eastern Mexico, and one of the most cultured on the southern United States. Consequently, the aim of this study was to investigate if there were significant differences in growth among channel catfish juveniles when fed diets containing various carotenoid doses from a natural source

Short communication: Effects of the addition of a marigold extract to diets fed to channel catfish (Ictalurus punctatus) on growth parameters

The expansion of aquaculture in the last 10 years has made it an important source of protein worldwide. However, increased production, and the culture intensification it carries, results in higher risk of infectious disease due to poor water quality and high stocking densities. ... Marigold (Tagetes erecta L.) is a plant native to Mexico whose flowers accumulate carotenoids. Natural carotenoids extracted from marigold have been used in aquaculture to help in the survival of fish juvenile stages by strengthening their immunological system, thus reducing mortality rates. The effect of carotenoids in fish health may exert a positive effect on fish growth indices; however, these effects on growth parameters have not been studied in channel catfish (Ictalurus punctatus), which is the most cultured fish species in north-eastern Mexico, and one of the most cultured on the southern United States. Consequently, the aim of this study was to investigate if there were significant differences in growth among channel catfish juveniles when fed diets containing various carotenoid doses from a natural source

A 2.5MHz bandpass active complex filter With 2.4MHz bandwidth for wireless communications

Trabajo presentado al 23rd DCIS celebrado en grenoble del 12 al 14 de noviembre de 2008.This paper presents a fully differential 8th order transconductor-based active complex filter with 2.4MHz bandwidth and centered at 2.5MHz, designed in a 90nm 2.5V 7M and MIM capacitors CMOS process technology. The filter compliants with the requirements of the IEEE802.15.4 standard. Simulation results including mismatching and process variations over the extracted view of the circuit are shown. The filter has a nominal gain of 12dB, good selectivity (20dB@2MHz offset), high image rejection (51dB nominal) and low power consumption (3.6mA @2.5V).This work has been founded in part by the EC through the project A109-Medea+ WITNESS (Wireless technologies for small area networks with embedded security and safety), the Spanish Regional Government of Junta de Andalucía under project TIC-927 and the Spanish Government under project TEC2007-68072.Peer reviewe

Deep crustal structure and continent-ocean boundary along the Galicia continental margin (NW Iberia)

The Galicia continental margin is a magma-poor rifted margin with an extremely complex structure. Its formation involves several rifting episodes during the Mesozoic in the vicinity of a ridge triple junction, which produces a change in the orientation of the main structures. In addition, there is an overimposed Cenozoic partial tectonic inversion along its northern border. Although this continental margin has been widely studied since the 70’s, most studies have focused on its western part in the transition to the Iberia Abyssal Plain, and there is a significant lack of information on the north and northwestern flanks of this margin. This fact, along with its great structural complexity, has resulted in the absence of a previous comprehensive regional geodynamic model integrating all the processes observed. In the present study we integrate a large volume of new geophysical data (gravity, swath bathymetry and 2D multichannel reflection seismic). Data come from the systematic mapping of the Spanish EEZ project which provides a dense grid of gravity data and full seafloor coverage with swath bathymetry, and from the ERGAP project which provides serially-arranged 2D seismic reflection profiles across the NW Iberia margin. The combined interpretation and modelling of this new information has arisen significant constraints on the origin, the deep crustal structure and the physiographic complexity of the margin, as well as on the characterization of the along- and across-strike variation of the ocean-continent transition along NW Iberia margin. The analysis of this information leads us to propose a conceptual model for the initiation of the tectonic inversion of a magma-poor rifted margin. Finally, a framework for the geodynamic evolution of the Galicia margin has been constructed, involving three main stages: A) an early stage from the end of rifting and oceanic drift in the Bay of Biscay (Santonian); B) an intermediate stage with the beginning of tectonic inversion in the north and northwestern Iberia margin (Campanian-Paleocene) mainly concentrated along the exhumed mantle zone; and C) a final stage of compressive deformation (Eocene-Oligocene) affecting both the continental and the oceanic crust, evidenced by large dip-slip thrusting.0,000

Residualidad del herbicida integrity en maíz, y el efecto agcelence de Headline (pyraclostrobin) en la remisión de síntomas de fitotoxicidad en chile, jitomate y calabaza, en Cuautla, Morelos

Algunos herbicidas según su estructura y características fisicoquímicas persisten en el ambiente y es de gran importancia conocer con certeza el tiempo en el cual la molécula química persiste adherida a las partículas del suelo, para determinar el momento oportuno en el cual es posible establecer el siguiente cultivo sin que haya problemas de fitotoxicidad propiciando por la acumulación de residuos en agua y suelo principalmente subiendo después por la cadena trófica y llegando hasta los seres humanos por consumo de alimentos, principalmente hortalizas de pocos días de desarrollo. La presente investigación determinó el efecto residual del herbicida Integrity, así como el efecto del fungicida Headline como promotor del efecto Agcelence para la remisión de síntomas de fitotoxicidad en la rotación de maíz con hortalizas,  en  donde  los  resultados  fueron  los  siguientes:  Integrity  no  ocasionó  síntomas  de fitotoxicidad a la dosis comercial (1.5 L.ha-1) aplicado en post-emergencia al cultivo, sin embargo las plantas de maíz presentaron una menor altura, se observó efecto residual hasta los 75 dias después de la aplicación en el testigo sin Headline tanto en chile, calabaza y jitomate; se encontró que Headline (pyraclostrobin) en su dosis alta (2.5 mL.L-1) ayuda en la remisión de los síntomas de fitotoxicidad ocasionados por el herbicida Integrity en un nivel agronómicamente aceptable (< 12.5 % de fitotoxicidad) en jitomate y calabaza

Optical and Infrared Imaging and Spectroscopy of the Multiple-Shell Planetary Nebula NGC 6369

NGC 6369 is a double-shell planetary nebula (PN) consisting of a bright annular inner shell with faint bipolar extensions and a filamentary envelope. We have used ground- and space-based narrow-band optical and near-IR images, broad-band mid-IR images, optical long-slit echelle spectra, and mid-IR spectra to investigate its physical structure. These observations indicate that the inner shell of NGC 6369 can be described as a barrel-like structure shape with polar bubble-like protrusions, and reveal evidence for H2 and strong polycyclic aromatic hydrocarbons (PAHs) emission from a photo-dissociative region (PDR) with molecular inclusions located outside the bright inner shell. High-resolution HST narrow-band images reveal an intricate excitation structure of the inner shell and a system of "cometary" knots. The knotty appearance of the envelope, the lack of kinematical evidence for shell expansion and the apparent presence of emission from ionized material outside the PDR makes us suggest that the envelope of NGC 6369 is not a real shell, but a flattened structure at its equatorial regions. We report the discovery of irregular knots and blobs of diffuse emission in low-excitation and molecular line emission that are located up to 80" from the central star, well outside the main nebular shells. We also show that the filaments associated to the polar protrusions have spatial extents consistent with post-shock cooling regimes, and likely represent regions of interaction of these structures with surrounding material.Comment: 14 pages, 13 figures. Accepted for publication in MNRA

Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits

Atherosclerosis represents a major cause of death in the world. It is known that Lipofundin 20% induces atherosclerotic lesions in rabbits, but its effects on serum lipids behaviour and redox environment have not been addressed. In this study, New Zealand rabbits were treated with 2 mL/kg of Lipofundin for 8 days. Then, redox biomarkers and serum lipids were determined spectrophotometrically. On the other hand, the development of atherosclerotic lesions was confirmed by eosin/hematoxylin staining and electron microscopy. At the end of the experiment, total cholesterol, triglycerides, cholesterol-LDL, and cholesterol-HDL levels were significantly increased. Also, a high index of biomolecules damage, a disruption of both enzymatic and nonenzymatic defenses, and a reduction of nitric oxide were observed. Our data demonstrated that Lipofundin 20% induces hyperlipidemia, which promotes an oxidative stress state. Due to the importance of these phenomena as risk factors for atherogenesis, we suggest that Lipofundin induces atherosclerosis mainly through these mechanisms

Chapter 14 - Regional development and cooperation

This chapter provides an assessment of knowledge and practice on regional development and cooperation to achieve climate change mitigation. It will examine the regional trends and dimensions of the mitigation challenge. It will also analyze what role regional initiatives, both with a focus on climate change and in other domains such as trade, can play in addressing these mitigation challenges. The regional dimension of mitigation was not explicitly addressed in the IPCC Fourth Assessment Report (AR4). Its discussion of policies, instruments, and cooperative agreements (Working Group III AR4, Chapter 13) was focused primarily on the global and national level. However, mitigation challenges and opportunities differ significantly by region. This is particularly the case for the interaction between development / growth opportunities and mitigation policies, which are closely linked to resource endowments, the level of economic development, patterns of urbanization and industrialization, access to finance and technology, and - more broadly - the capacity to develop and implement various mitigation options. There are also modes of regional cooperation, ranging from regional initiatives focused specifically on climate change (such as the emissions trading scheme (ETS) of the European Union (EU)) to other forms of cooperation in the areas of trade, energy, or infrastructure, that could potentially provide a platform for delivering and implementing mitigation policies. These dimensions will be examined in this chapter. Specifically, this chapter will address the following questions: - Why is the regional level important for analyzing and achieving mitigation objectives? - What are the trends, challenges, and policy options for mitigation in different regions? - To what extent are there promising opportunities, existing examples, and barriers for leapfrogging in technologies and development strategies to low-carbon development paths for different regions? - What are the interlinkages between mitigation and adaptation at the regional level? - To what extent can regional initiatives and regional integration and cooperation promote an agenda of low-carbon climate-resilient development? What has been the record of such initiatives, and what are the barriers? Can they serve as a platform for further mitigation activities

<i>orsai</i>, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control

BACKGROUND: Lipid homeostasis is an evolutionarily conserved process that is crucial for energy production, storage and consumption. Drosophila larvae feed continuously to achieve the roughly 200-fold increase in size and accumulate sufficient reserves to provide all energy and nutrients necessary for the development of the adult fly. The mechanisms controlling this metabolic program are poorly understood. RESULTS: Herein we identified a highly conserved gene, orsai (osi), as a key player in lipid metabolism in Drosophila. Lack of osi function in the larval fat body, the regulatory hub of lipid homeostasis, reduces lipid reserves and energy output, evidenced by decreased ATP production and increased ROS levels. Metabolic defects due to reduced Orsai (Osi) in time trigger defective food-seeking behavior and lethality. Further, we demonstrate that downregulation of Lipase 3, a fat body-specific lipase involved in lipid catabolism in response to starvation, rescues the reduced lipid droplet size associated with defective orsai. Finally, we show that osi-related phenotypes are rescued through the expression of its human ortholog ETFRF1/LYRm5, known to modulate the entry of β-oxidation products into the electron transport chain; moreover, knocking down electron transport flavoproteins EtfQ0 and walrus/ETFA rescues osi-related phenotypes, further supporting this mode of action. CONCLUSIONS: These findings suggest that Osi may act in concert with the ETF complex to coordinate lipid homeostasis in the fat body in response to stage-specific demands, supporting cellular functions that in turn result in an adaptive behavioral response. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12915-022-01417-w